منابع مشابه
Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster.
KFase (kynurenine formamidase), also known as arylformamidase and formylkynurenine formamidase, efficiently catalyses the hydrolysis of NFK (N-formyl-L-kynurenine) to kynurenine. KFase is the second enzyme in the kynurenine pathway of tryptophan metabolism. A number of intermediates formed in the kynurenine pathway are biologically active and implicated in an assortment of medical conditions, i...
متن کاملStructures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile
Tryptophan is an important precursor for chemical entities that ultimately support the biosynthesis of key metabolites. The second stage of tryptophan catabolism is catalysed by kynurenine formamidase, an enzyme that is different between eukaryotes and prokaryotes. In the present study, we characterize the catalytic properties and present the crystal structures of three bacterial kynurenine for...
متن کاملThe Kynurenine Transaminase of Rat Kidney*
The conversion of kynurenine to kynurenic acid was observed in intact animals by Kotake (2) in 1931. This reaction was studied in vitro by Mason and Berg (3, 4), who observed that slices and homogenates of rat liver converted both tryptophan and kynurenine to kynurenic acid. Similar preparations from rat kidney did not convert tryptophan to kynurenine or kynurenic acid, but had a somewhat great...
متن کاملThe kynurenine transaminase of rat kidney.
The conversion of kynurenine to kynurenic acid was observed in intact animals by Kotake (2) in 1931. This reaction was studied in vitro by Mason and Berg (3, 4), who observed that slices and homogenates of rat liver converted both tryptophan and kynurenine to kynurenic acid. Similar preparations from rat kidney did not convert tryptophan to kynurenine or kynurenic acid, but had a somewhat great...
متن کاملKynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage
The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in various neuropsychiatric and neurodegenerative diseases, immunological disorders, and many other diseased states. Although the role of the KP in the skin has been ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1969
ISSN: 0022-202X
DOI: 10.1038/jid.1969.74